Gut Health, Hormones, Fat Loss, and GLP-1's with Professor Max Nieuwdorp
In this episode of Inside Matters, Dr James McIlroy is joined by Professor Max Nieuwdorp of Amsterdam University Medical Centres for a deep and wide-ranging conversation on the microbiome, hormones, and their profound impact on metabolic health.
From obesity and diabetes to emerging insights in cancer care, this episode explores how faecal microbiota transplantation (FMT) and novel pharmaceutical strategies are redefining what’s possible in the treatment of chronic disease.
Professor Nieuwdorp recounts his unexpected entry into microbiome research during his postdoctoral years in California, where early breakthroughs in FMT—particularly for C. difficile—sparked a lifelong fascination. His work has since positioned him at the forefront of microbiome science as he investigates how our gut bacteria influence weight, metabolism, and hormonal balance.
The conversation touches on everything from genetic influences on obesity and the challenges of sustained weight loss, to the exciting potential of GLP-1 drugs and next-generation probiotics. There’s also a fascinating look at how the microbiome might act as both a diagnostic and therapeutic tool in future medicine.
Finally, Max shares highlights from his book The Power of Hormones, which brings together history, science, and practical advice for anyone curious about how hormones and the microbiome shape our lives.
This episode offers an insightful look at where cutting-edge science meets real-world potential—and why the microbiome could be the key to a healthier future.
Timestamps:
00:00 – Introduction to Professor Max and the podcast
02:04 – Max’s journey into microbiome research
05:06 – The power of faecal microbiota transplantation (FMT)
08:11 – Microbiome’s role in obesity and metabolic health
10:42 – Challenges and future directions
14:47 – Defining obesity and genetic predispositions
18:39 – The expanding reach of FMT
23:48 – What makes a healthy diet for the gut
31:07 – Combining probiotics for better outcomes
31:36 – The GLP-1 story: a closer look
32:30 – Mechanisms and effects of GLP-1 drugs
37:26 – Microbiome and long-term weight management
39:18 – Selecting the right donor for FMT
42:27 – Diet, microbiome, and whole-body health
50:17 – Future therapies and innovations
56:13 – Highlights from The Power of Hormones